LTURM 34

Key Product Details

Product Description

LTURM 34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro. LTURM 34 also increases CRISPR-Cas9 deletion efficiency.

Product Specifications for LTURM 34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LTURM 34

The following data is based on the product molecular weight 414.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.83 mL	24.13 mL	48.25 mL
2.5 mM	0.97 mL	4.83 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bosch-Guiteras Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. Genome Res. 2021 PMID: 33574136
• Morrison Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 2016 PMID: 26854431

Product Documents for LTURM 34