Potent DNA-PK inhibitor (IC50
= 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines.
Morrison et al.