Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Biological ActivityLY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors.
Croy et al.
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Kruse et al.
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