Chemical Name: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
Biological ActivityPotent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376.
Suman-Chauhan et al.
Quinazolinone cholecystokinin receptor ligands.
Yu et al.
Citations for LY 225910
The citations listed below are publications that use Tocris products. Selected citations for LY 225910 include:
3 Citations: Showing 1 - 3
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia.
Authors: Seillier Et al.
Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
Authors: Karson Et al.
J Card Fail 2008;54:117
Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
Authors: Gallopin Et al.
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