Catalog Number: 1018
Chemical Name: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
Biological Activity
Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).
Technical Data
  • M.Wt:
    502.41
  • Formula:
    C27H24BrN3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    133040-77-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company.
Background References
  1. The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376.
    Suman-Chauhan et al.
    Regul.Pept., 1996;65:37
  2. Quinazolinone cholecystokinin receptor ligands.
    Yu et al.
    J.Med.Chem., 1991;34:1505
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 225910 include:

3 Citations: Showing 1 - 3
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  1. Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia.
    Authors: Seillier Et al.
    Neuropharmacology 2013;38:1816
  2. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
    Authors: Karson Et al.
    J Card Fail 2008;54:117
  3. Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
    Authors: Gallopin Et al.
    Neuropsychopharmacology 2006;16:1440

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