Catalog Number: 1019
Chemical Name: [3S-(3α,4aα,6β,8aα)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)
Biological Activity
Competitive NMDA receptor antagonist.
Technical Data
  • M.Wt:
    277.26
  • Formula:
    C11H20NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
    137433-06-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company.
Background References
  1. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
    Borowicz et al.
    Epilepsia, 1996;37:618
  2. Competitive and non-competitive NMDA antagonists induce similar limbic degeneration.
    Ellison
    Neuroreport, 1994;5:2688
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 235959 include:

2 Citations: Showing 1 - 2
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  1. Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
    Authors: Fowler Et al.
    Nature 2011;471:597
  2. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.
    Authors: Kenny Et al.
    Neuropsychopharmacology 2009;34:266

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