Prototypical PI 3-kinase inhibitor (IC
values are 0.31, 0.73, 1.06 and 6.60
M for PI 3-K
, PI 3-K
, PI 3-K
and PI 3-K
respectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in human colon cancer cells
. Suppresses proliferation of mESCs. Inhibits autophagic sequestration in rat hepatocytes.
Negative Control also available. View R&D Systems' research poster featuring LY 294002 hydrochloride.
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Other Product-Specific Information:
Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells.
Lianguzova et al.
Cell Biol.Int., 2007;31:330
The selectivity of protein kinase inhibitors: a further update.
Bain et al.
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Blommaart et al.
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002).
Vlahos et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 294002 hydrochloride include:
60 Citations: Showing 1 - 10 Filter your results:
miR-382 targeting PTEN-Akt axis promotes liver regeneration. Authors: Bei Et al. Elife 2016;7:1584 The GABA B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABA B receptors Authors: Olianas Et al. European Journal of Pharmacology 2016;794:135 Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling Authors: Shao-Hua Su Et al. Behavioural Brain Research 2016;313:334 Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Authors: Mou Et al. Cell: Stem Cell 2016;19:217 Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia. Authors: Oliveira Et al. Int J Mol Med 2016;13:11 Up-Regulated Expression of LAMP2 and Autophagy Activity during Neuroendocrine Differentiation of Prostate Cancer LNCaP Cells Authors: Morell Et al. PLoS One 2016;11:e0162977 Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Authors: Najm Et al. Int J Cancer 2015;522:216 Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. Authors: Lindström Et al. J Biomed Sci 2015;3:e04000 The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes. Authors: Yu and Kim Alcohol Clin Exp Res 2015;35:325 Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction. Authors: Gudasheva Et al. Nature 2015;22:106 A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation. Authors: Cao Et al. Oncotarget 2015;172:1869 SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Authors: Choi Et al. PLoS One 2015;136:E219 An in vitro model of latency and reactivation of varicella zoster virus in human stem cell-derived neurons. Authors: Markus Et al. PLoS Pathog 2015;11:e1004885 Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Authors: Rogers and Gahring J Neuroinflammation 2015;10:e0143319 Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life. Authors: Laube Et al. PLoS One 2015;10:e0124833 ER-α36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem/progenitor cells. Authors: Deng Et al. BMC Cancer 2014;9:e88034 Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α. Authors: Gonsalves Et al. Am J Hematol 2014;89:273 Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Authors: Dai Et al. Glia 2014;62:2096 Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Authors: Mattes Et al. Physiol Rep 2014;2:e00269 Decrease of PKB/Akt Phosphorylation is Partially Mediated by SAPK/JNK Activation in Serum-free L6 Myoblasts Starved with Low Glucose. Authors: Kim Et al. J Phys Ther Sci 2014;26:1757 δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Authors: Liang Et al. J Exp Bot 2014;171:5417 Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. Authors: Bayliss and Evans PLoS One 2013;8:e80833 ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. Authors: Montané and Menand Neuroscience 2013;64:4361 Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. Authors: Yung Et al. J Steroid Biochem Mol Biol 2013;13:327 Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Authors: Gangoiti Et al. Biochimie 2012;94:597 Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways. Authors: Lee Et al. PLoS One 2012;7:e50624 Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Authors: Cozzoli Et al. Cancer Res 2012;36:1623 The canonical nuclear factor-κB pathway regulates cell survival in a developmental model of spinal cord motoneurons. Authors: Mincheva Et al. J Neurosci 2011;31:6493 JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. Authors: Hsu Et al. J Med Food 2011;18:61 A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells. Authors: Kang Et al. J Pharmacol Exp Ther 2011;127:262 Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. Authors: Barrio Et al. Toxicol Sci 2011;123:193 Leptin regulates AMPA receptor trafficking via PTEN inhibition. Authors: Moult Et al. J Neurosci 2010;30:4088 Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept Authors: Sunters Et al. J Biol Chem 2010;285:8743 miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Authors: Zhou Et al. Blood 2010;116:5885 Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Authors: Brinks Et al. J Cell Sci 2010;107:1140 FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation. Authors: Grodzki Et al. Circ Res 2009;46:2539 Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Authors: Li Et al. J Biol Chem 2009;29:15551 Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor. Authors: Solyakov Et al. Oncogene 2009;28:3619 Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis. Authors: Wang Et al. Mol Biol Cell 2009;20:4153 Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. Authors: Yeligar Et al. J Immunol 2009;183:5964 Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. Authors: Yeligar Et al. J Immunol 2009;183:5232 c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells. Authors: Garcia Et al. J Immunol 2009;183:4475 C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Authors: Morris Et al. Am J Respir Crit Care Med 2009;180:19 Soy phytoestrogens are neuroprotective against stroke-like injury in vitro. Authors: Schreihofer and Redmond J Neurosci 2009;158:602 Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. Authors: Tsuda Et al. J Cell Mol Med 2009;13:3251 Inulin increases glucose transport in C2C12 myotubes and HepG2 cells via activation of AMP-activated protein kinase and phosphatidylinositol 3-kinase pathways. Authors: Yun Et al. PLoS One 2009;12:1023 Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Authors: Jung Et al. Carcinogenesis 2008;29:713 Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. Authors: Pezet Et al. J Neurosci 2008;28:4261 Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons. Authors: Nelson Et al. J Neurochem 2008;107:602 Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Authors: González-Maeso Et al. Exp Mol Med 2007;53:439 Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Authors: Park Et al. Br J Pharmacol 2007;39:222 cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. Authors: Hwang Et al. Carcinogenesis 2007;28:363 Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. Authors: Zapata Et al. J Biol Chem 2007;282:35842 IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. Authors: Chung Et al. J Endocrinol 2007;194:77 Insulin induces airway smooth muscle contraction. Authors: Schaafsma Et al. J Biomed Sci 2007;150:136 PI-3-kinase-dependent membrane recruitment of centaurin-α2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation. Authors: Venkateswarlu Et al. Neuron 2007;120:792 Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells. Authors: Kilker and Planas-Silva Mol Immunol 2006;66:11478 Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. Authors: Qiu Et al. Br J Pharmacol 2006;26:12943 Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. Authors: Yun Et al. J Neurosci 2005;280:9963 LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II. Authors: Searl and Silinsky Purinergic Signal 2005;1:389
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