Catalog Number: 2814
Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Biological Activity
PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.
Technical Data
  • M.Wt:
    322.36
  • Formula:
    C19H18N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    942289-87-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Exploring the specificity of the PI3K family inhibitor LY294002.
    Gharbi et al.
    Biochem.J., 2007;404:15
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PI 828 include:

3 Citations: Showing 1 - 3
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  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    J Neurosci 2015;10:e0143319
  2. Functional kinomics identifies candidate therapeutic targets in head and neck cancer.
    Authors: Moser Et al.
    Clin Cancer Res 2014;20:4274
  3. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res 2013;14:134
Tocris Small Molecules
Description Application Cat# Citations Images  

LY 294002 hydrochloride

1130 60  
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