PI 828

Catalog # Availability Size / Price Qty
2814/1
2814/10
PI 828 | CAS No. 942289-87-4 | PI 3-Kinase Inhibitors
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Description: PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one

Purity: ≥99%

Product Details
Citations (5)
Supplemental Products
Reviews (1)

Biological Activity

PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Technical Data

M.Wt:
322.36
Formula:
C19H18N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
942289-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Exploring the specificity of the PI3K family inhibitor LY294002.
    Gharbi et al.
    Biochem.J., 2007;404:15

Product Datasheets

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Citations for PI 828

The citations listed below are publications that use Tocris products. Selected citations for PI 828 include:

5 Citations: Showing 1 - 5

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Treat PI828 for HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized
By Scott Rogers on 10/01/2019
Species: Human

The HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized, and they were maintained as described previously. This cell line also expresses TNFR1 (only weak expression of TNFR2 is detected) and no additional human nAChR subunits or acetylcholine synthetic enzymes are detected. As before PI 828 (20 nM) treatments were conducted 48 hours after cell plating


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