Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Biological ActivityPI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Exploring the specificity of the PI3K family inhibitor LY294002.
Gharbi et al.
Citations for PI 828
The citations listed below are publications that use Tocris products. Selected citations for PI 828 include:
5 Citations: Showing 1 - 5
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Authors: Liddell Et al.
J Neuroinflammation 2016;13:49
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
J Neurosci 2015;10:e0143319
Functional kinomics identifies candidate therapeutic targets in head and neck cancer.
Authors: Moser Et al.
Clin Cancer Res 2014;20:4274
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
Authors: Li Et al.
Environ Health Perspect 2011;119:784
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Reviews for PI 828
Average Rating: 5 (Based on 1 Review)
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The HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized, and they were maintained as described previously. This cell line also expresses TNFR1 (only weak expression of TNFR2 is detected) and no additional human nAChR subunits or acetylcholine synthetic enzymes are detected. As before PI 828 (20 nM) treatments were conducted 48 hours after cell plating