PI 828

Tocris Bioscience | Catalog # 2814

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
Tocris Bioscience

Key Product Details

Description

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
View all PI 3-Kinase Inhibitors »

Product Description

PI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Product Specifications for PI 828

Molecular Weight

322.36

Formula

C19H18N2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one

CAS Number

942289-87-4

PubChem ID

25181195

InChI Key

WUKMIBOGGXMBAC-UHFFFAOYSA-N

SMILES

O=C2C=C(N3CCOCC3)OC1=C(C4=CC=C(N)C=C4)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.24 100

Preparing Stock Solutions for PI 828

The following data is based on the product molecular weight 322.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.10 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.10 mL 6.20 mL
10 mM 0.31 mL 1.55 mL 3.10 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Product Documents for PI 828

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PI 828

For research use only

Customer Reviews for PI 828 (1)

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  • Treat PI828 for HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized
    Name: Wen Ding
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: 293
    Verified Customer | Posted 10/01/2019
    The HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized, and they were maintained as described previously. This cell line also expresses TNFR1 (only weak expression of TNFR2 is detected) and no additional human nAChR subunits or acetylcholine synthetic enzymes are detected. As before PI 828 (20 nM) treatments were conducted 48 hours after cell plating
    PI 828 2814

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