Catalog Number: 2418
Chemical Name: 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
Biological Activity
Negative control compound with respect to LY 294002 (Cat. No. 1130) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism.
    El-kholy et al.
    FASEB J., 2003;17:720
  2. LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.
    Choi et al.
    FEBS Letters., 2004;559:141
  3. LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
    Kristof et al.
    J.Pharmacol.Exp.Ther., 2005;314:1134
Tocris Small Molecules
Description Application Cat# Citations Images  

LY 294002 hydrochloride

1130 59  
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