Negative control compound with respect to LY 294002
(Cat. No. 1130) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv
) channels (IC50
= 64.6 μ
M) and inhibits IL-1β
B activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism.
El-kholy et al.
FASEB J., 2003;17:720
LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.
Choi et al.
FEBS Letters., 2004;559:141
LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
Kristof et al.