LY 3009120

Catalog # Availability Size / Price Qty
6854/50
6854/10
LY 3009120 | CAS No. 1454682-72-4 | Raf Kinase Inhibitors
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Description: Potent pan-Raf kinase inhibitor

Chemical Name: N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent pan-Raf kinase inhibitor (IC50 values are 31 - 47, 42 and 44 nM for b-RAF, c-RAF and a-RAF in A375 cells, respectively). Also inhibits kinase activity of Raf hetero- and homodimers. Displays antiproliferative effects against b-RAF and Ras mutant melanoma cells. Inhibits MEK and ERK phosphorylation, and b-RAF and Ras mutant tumor growth in mouse xenograft models.

Technical Data

M.Wt:
424.52
Formula:
C23H29FN6O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1454682-72-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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