Home / Cannabinoid R1 / CB1 Inverse Agonists / LY 320135

LY 320135

Catalog #: 2387
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2387/10
2387/50
LY 320135 | CAS No. 176977-56-3 | Cannabinoid R1 / CB1 Inverse Agonists
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Description: Selective CB1 inverse agonist

Chemical Name: 4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

LY 320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM).

Technical Data

M.Wt:
383.4
Formula:
C24H17NO4
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
176977-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for LY 320135

The citations listed below are publications that use Tocris products. Selected citations for LY 320135 include:

4 Citations: Showing 1 - 4

  1. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
    Authors: Stanley Et al.
    J Neurosci  2015;107:568
  2. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  3. Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.
    Authors: Morgan Et al.
    Neural Plast  2008;2008:808564
  4. Cannabinoid action in the olfactory epithelium.
    Authors: Czesnik Et al.
    Proc Natl Acad Sci U S A  2007;104:2967

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VersaClone cDNA Plasmids

Human Cannabinoid R1/CB1/CNR1 (NP_057167) VersaClone cDNA

RDC0109

Mouse Cannabinoid R1/CB1/CNR1 (NP_031752) VersaClone cDNA

RDC0222

Rat Cannabinoid R1/CB1/CNR1 (NP_036916) VersaClone cDNA

RDC0757

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