LY 320135

Key Product Details

Product Description

LY 320135 is a potent CB₁ receptor antagonist/inverse agonist (K_i = 141 nM) with greater than 70-fold selectivity over CB₂ receptors (K_i > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT₂ (K_i = 6.4 μM) and muscarinic receptors (K_i = 2.1 μM).

Product Specifications for LY 320135

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 320135

The following data is based on the product molecular weight 383.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	8.69 mL	43.47 mL	86.94 mL
1.5 mM	1.74 mL	8.69 mL	17.39 mL
3 mM	0.87 mL	4.35 mL	8.69 mL
15 mM	0.17 mL	0.87 mL	1.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Holland Cannabinoid CB₁ receptors fail to cause relaxation, but couple via G_i/G_o to the inhibition of adenylyl cyclase in carotid artery smooth muscle. Br.J.Pharmacol. 1999 PMID: 10516638
• Pertwee Inverse agonism and neutral antagonism at cannabinoid CB₁ receptors. Life Sci. 2005 PMID: 15670612
• Felder LY320135, a novel cannabinoid CB₁ receptor antagonist, unmasks coupling of the CB₁ receptor to stimulation of cAMP accumulation. J.Pharmacol.Exp.Ther. 1998 PMID: 9435190

Product Documents for LY 320135