LY 320135

  ( 4 citations )    
Product Datasheet
Catalog Number:2387
Chemical Name:4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile
Product Details
Citations (4)
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Biological Activity
Potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM).
Technical Data
  • M.Wt:
    383.4
  • Formula:
    C24H17NO4
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    176977-56-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 320135 include:

4 Citations: Showing 1 - 4
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  1. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
    Authors: Stanley Et al.
    J Neurosci  2015;107:568
  2. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  3. Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.
    Authors: Morgan Et al.
    Neural Plast  2008;2008:808564
  4. Cannabinoid action in the olfactory epithelium.
    Authors: Czesnik Et al.
    Proc Natl Acad Sci U S A  2007;104:2967

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