LY 334370 hydrochloride

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3079/10
3079/50
LY 334370 hydrochloride | CAS No. 199673-74-0 | 5-HT1F Receptor Agonists
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Description: Selective 5-HT1F agonist

Chemical Name: 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Reviews

Biological Activity

Selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.

Technical Data

M.Wt:
387.88
Formula:
C21H22FN3O.HCl
Solubility:
Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
199673-74-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Eli Lilly and company

Background References

  1. G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines.
    Dupuis et al.
    Br.J.Pharmacol., 1998;124:283
  2. Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370.
    Shepheard et al.
    Cephalalgia, 1999;19:851
  3. [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.
    Wainscott et al.
    Naunyn-Schmied.Arch.Pharmacol., 2005;371:169

Product Datasheets

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Citation for LY 334370 hydrochloride

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