receptor agonist (Ki
values are 1.87, 16.4, > 100 (IC50
), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50
) and 3250 nM for 5-HT1F
receptors respectively). Displays antimigraine effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from Eli Lilly and company
G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines.
Dupuis et al.
Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370.
Shepheard et al.
[H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.
Wainscott et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 334370 hydrochloride include:
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