LY 334370 hydrochloride
Chemical Name: 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride
Biological ActivitySelective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines.
Dupuis et al.
Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370.
Shepheard et al.
[H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.
Wainscott et al.
Citation for LY 334370 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LY 334370 hydrochloride include:
1 Citation: Showing 1 - 1
Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.
Authors: Garrett Et al.
J Pharmacol Exp Ther 2014;350:257
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for LY 334370 hydrochloride
There are currently no reviews for this product. Be the first to review LY 334370 hydrochloride and earn rewards!
Have you used LY 334370 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image