(±)-LY 395756

Key Product Details

Product Description

(±)-LY 395756 is a selective metabotropic glutamate ligand for mGlu₂ and mGlu₃ receptors (K_i values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu₂ and antagonist at mGlu₃. Analog of LY 354740 (Cat. No. 3246).

Product Specifications for (±)-LY 395756

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-LY 395756

The following data is based on the product molecular weight 199.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.10 mL	50.20 mL
5 mM	1.00 mL	5.02 mL	10.04 mL
10 mM	0.50 mL	2.51 mL	5.02 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Dominguez Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 2005 PMID: 15887967

Product Documents for (±)-LY 395756