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(±)-LY 395756

Catalog #: 3272
2 Citations Datasheet / COA / SDS

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3272 has been discontinued.
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(±)-LY 395756 | CAS No. 852679-66-4 | Glutamate Receptor Compounds
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Description: Mixed mGlu2 agonist/ mGlu3 antagonist

Chemical Name: (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(±)-LY 395756 is a selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).

Technical Data

M.Wt:
199.21
Formula:
C9H13NO4
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
852679-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (±)-LY 395756

The citations listed below are publications that use Tocris products. Selected citations for (±)-LY 395756 include:

2 Citations: Showing 1 - 2

  1. Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum.
    Authors: Johnson
    Neuropharmacology  2017;117:114
  2. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    Mol Pain  2013;8:e61787

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