Highly selective and potent agonist of group II mGlu receptors (EC50
values are 5.1 and 24.3 nM at mGlu2
receptors respectively and > 100000 nM at mGlu4
receptors). Displays antianxiety and antiaddictive activity in vivo
. Orally and systemically active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.
Klodzinska et al.
LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors.
Schoepp et al.
Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.
Helton et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 354740 include:
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