Catalog Number: 3246
Chemical Name: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Biological Activity
Highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and > 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.
Technical Data
  • M.Wt:
    185.18
  • Formula:
    C8H11NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    176199-48-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.
    Klodzinska et al.
    Neuropharmacology, 1999;38:1831
  2. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors.
    Schoepp et al.
    Neuropharmacology, 1997;36:1
  3. Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.
    Helton et al.
    J.Pharmacol.Exp.Ther., 1998;284:651
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 354740 include:

3 Citations: Showing 1 - 3
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors.
    Authors: Copeland Et al.
    Sci Rep 2015;92:16
  3. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
    Authors: Yaeger and Trussell
    J Neurosci 2015;35:4741

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