LY 354740

  ( 4 citations )    
Product Datasheet
Catalog Number:3246
Chemical Name:(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and > 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.
Technical Data
  • M.Wt:
    185.18
  • Formula:
    C8H11NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    176199-48-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 354740 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
    Authors: Dornier
    Nat Commun  2017;8(1):2255
  2. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  3. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors.
    Authors: Copeland Et al.
    Sci Rep  2015;92:16
  4. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
    Authors: Yaeger and Trussell
    J Neurosci  2015;35:4741

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used LY 354740?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee