LY 450139

Tocris Bioscience | Catalog # 6559

γ-secretase pseudo-inhibitor
Tocris Bioscience

Key Product Details

Description

γ-secretase pseudo-inhibitor
View all gamma-Secretase Modulators »

Product Description

LY 450139 is a γ-secretase pseudo-inhibitor. Inhibits Aβ secretion from cells in vitro and increases accumulation of γ-secretase products and long Aβ species in vitro and in vivo. Also attenuates the accumulation of activated microglia and neurological injury in a traumatic brain injury animal model.

Product Specifications for LY 450139

Molecular Weight

361.44

Formula

C19H27N3O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide

CAS Number

425386-60-3

PubChem ID

9843750

InChI Key

PKXWXXPNHIWQHW-RCBQFDQVSA-N

SMILES

CC([C@@H](C(N[C@H](C(N[C@H]1C2=CC=CC=C2CCN(C1=O)C)=O)C)=O)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100
Ethanol 18.07 50

Preparing Stock Solutions for LY 450139

The following data is based on the product molecular weight 361.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 450139

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 450139

For research use only

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