LY 450139

Catalog # Availability Size / Price Qty
6559/5
6559/25
Cat.No. 6559 - LY 450139 | C19H27N3O4 | CAS No. 425386-60-3
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Description: γ-secretase pseudo-inhibitor

Chemical Name: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

γ-secretase pseudo-inhibitor. Inhibits Aβ secretion from cells in vitro and increases accumulation of γ-secretase products and long Aβ species in vitro and in vivo. Also attenuates the accumulation of activated microglia and neurological injury in a traumatic brain injury animal model.

Technical Data

M.Wt:
361.44
Formula:
C19H27N3O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
425386-60-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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