Positive allosteric modulator selective for mGlu2
receptors. Potentiates glutamate-stimulated [35
S binding (EC50
values are 1.7 and > 10 μ
M for mGlu2
receptors respectively). Devoid of any activity at mGlu5
receptors. Promotes cognitive flexibility in a rat model.
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All Tocris products are intended for laboratory research use only.
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,-trifluoroethylsulfonyl)pyrid-3-ylmethyl-amine.
Johnson et al.
Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
Schaffhauser et al.
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.
Poisik et al.
Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats.
Nikiforuk et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 487379 hydrochloride include:
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