LY 487379 hydrochloride

Catalog # Availability Size / Price Qty
3283/10
3283/50
LY 487379 hydrochloride | CAS No. 353229-59-1 | Group II mGluR Modulators
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Description: Selective positive allosteric modulator of mGlu2 receptors

Chemical Name: 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity

Positive allosteric modulator selective for mGlu2 receptors. Potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Devoid of any activity at mGlu5 and mGlu7 receptors. Promotes cognitive flexibility in a rat model.

Technical Data

M.Wt:
488.91
Formula:
C21H19F3N2O4S.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
353229-59-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for LY 487379 hydrochloride

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4 Citations: Showing 1 - 4

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