LY 487379 hydrochloride

  ( 4 citations )    
Product Datasheet
Catalog Number:3283
Chemical Name:2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride
Product Details
Citations (4)
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Reviews
Biological Activity
Positive allosteric modulator selective for mGlu2 receptors. Potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Devoid of any activity at mGlu5 and mGlu7 receptors. Promotes cognitive flexibility in a rat model.
Technical Data
  • M.Wt:
    488.91
  • Formula:
    C21H19F3N2O4S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    353229-59-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 487379 hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
    Authors: Scholler
    Nat Commun  2017;8(1):1967
  2. Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors.
    Authors: Copeland Et al.
    Nat Commun  2015;92:16
  3. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.
    Authors: Motolese Et al.
    Neuropharmacology  2015;8:66
  4. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
    Authors: Yin Et al.
    J Neurosci  2014;34:79

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