LY 487379 hydrochloride

Key Product Details

Product Description

LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu₂ receptors. Potentiates glutamate-stimulated [³⁵S]GTPγS binding (EC₅₀ values are 1.7 and > 10 μM for mGlu₂ and mGlu₃ receptors respectively). Devoid of any activity at mGlu₅ and mGlu₇ receptors. Promotes cognitive flexibility in a rat model.

Product Specifications for LY 487379 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 487379 hydrochloride

The following data is based on the product molecular weight 488.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.45 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Nikiforuk Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J.Pharmacol.Exp.Ther. 2010 PMID: 20739457
• Schaffhauser Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol.Pharmacol. 2003 PMID: 14500736
• Poisik Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology 2005 PMID: 15993439
• Johnson Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,-trifluoroethylsulfonyl)pyrid-3-ylmethyl-amine. J.Med.Chem. 2003 PMID: 12852748

Product Documents for LY 487379 hydrochloride