High affinity inhibitor of phenylethanolamine-N
-methyltransferase (PNMT) (Ki
= 0.09 μ
M in vitro
). Suppresses the release of growth hormone in an in vivo
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Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine.
Fuller et al.
Regulation of episodic growth hormone secretion by the central epinephrine system.
Terry et al.
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
Grunewald et al.