Catalog Number: 4060
Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride
Biological Activity
High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine.
    Fuller et al.
    J.Med.Chem., 1973;16:106
  2. Regulation of episodic growth hormone secretion by the central epinephrine system.
    Terry et al.
    J.Clin.Invest., 1982;69:104
  3. Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
    Grunewald et al.
    J.Med.Chem., 1988;31:824
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