Catalog Number: 2265
Biological Activity
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.
Technical Data
  • M.Wt:
    2370.91
  • Formula:
    C115H184N30O24
  • Sequence:
    YGYRLRRKWEEKIPNP

    (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)

  • Solubility:
    Soluble to 10 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    222018-18-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor.
    Adachi et al.
    J.Immunol., 1999;162:1496
  2. A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation.
    Adachi et al.
    J.Immunol., 1999;163:939

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