Lyn peptide inhibitor
Biological Activity
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.Technical Data
(Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor.
Adachi et al.
J.Immunol., 1999;162:1496 -
A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation.
Adachi et al.
J.Immunol., 1999;163:939
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Citation for Lyn peptide inhibitor
The citations listed below are publications that use Tocris products. Selected citations for Lyn peptide inhibitor include:
1 Citation: Showing 1 - 1
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Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex.
Authors: Zhang Et al.
Exp Mol Med 2018;50:e439
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