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Lyn peptide inhibitor

2265 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2265/1
Lyn peptide inhibitor
1 Image
Description: Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
Product Details
Citations (1)
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Biological Activity

Lyn peptide inhibitor is a cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

Technical Data

M.Wt:
2370.91
Formula:
C115H184N30O24
Sequence:
YGYRLRRKWEEKIPNP

(Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)

Solubility:
Soluble to 10 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
222018-18-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Lyn peptide inhibitor

The citations listed below are publications that use Tocris products. Selected citations for Lyn peptide inhibitor include:

1 Citation: Showing 1 - 1

  1. Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex.
    Authors: Zhang Et al.
    Exp Mol Med  2018;50:e439

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