Catalog Number: 3228
Biological Activity
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
Technical Data
  • M.Wt:
    804
  • Formula:
    C39H65N9O9
  • Sequence:
    DKFVGLX

    (Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    137565-28-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay).
    Chassaing et al.
    Neuropeptides, 1991;19:91
  2. An investigation of tachykinin NK2 receptor subtypes in the rat.
    Matuszek et al.
    Eur.J.Pharmacol., 1998;352:103
  3. Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis.
    Burcher et al.
    J.Pharmacol.Exp.Ther., 2008;324:170

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