M 084 hydrochloride

Key Product Details

Product Description

M 084 hydrochloride is a TRPC4/5 channel blocker (IC₅₀ values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Product Specifications for M 084 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for M 084 hydrochloride

The following data is based on the product molecular weight 225.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.43 mL	22.15 mL	44.30 mL
5 mM	0.89 mL	4.43 mL	8.86 mL
10 mM	0.44 mL	2.22 mL	4.43 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Yang Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 2015 PMID: 26317356
• Zhu Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 2015 PMID: 25816897

Product Documents for M 084 hydrochloride