TRPC4/5 channel blocker (IC50
values are 3.7-10.3 and 8.2 μ
M, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo
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All Tocris products are intended for laboratory research use only.
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Zhu et al.
Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice.
Yang et al.
PLoS One, 2015;10:e0136255