Catalog Number: 5807
Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride
Biological Activity
TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.
Technical Data
  • M.Wt:
    225.72
  • Formula:
    C11H15N3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
    Zhu et al.
    Br.J.Pharmacol., 2015;172:3495
  2. Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice.
    Yang et al.
    PLoS One, 2015;10:e0136255
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