Catalog Number: 0440
Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride
Biological Activity
Prototypical potent and selective 5-HT3 receptor agonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide.
    Boess et al.
    Neuropharmacology, 1992;31:561
  2. 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist.
    Kilpatrick et al.
    Eur.J.Pharmacol., 1990;182:193
  3. Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment.
    Niemeyer and Lummis
    Br.J.Pharmacol., 1998;123:661
  4. The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells.
    Sepulveda et al.
    Br.J.Pharmacol., 1991;104:536

The citations listed below are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol 2014;28:891
  2. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol 2012;167:1480
  3. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
    Authors: Huang Et al.
    PLoS One 2009;29:13909
  4. Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.
    Authors: Gill Et al.
    Am J Physiol Gastrointest Liver Physiol 2008;295:G700

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