m-CPP hydrochloride

Name: m -CPP hydrochloride
Brand: Tocris Bioscience
SKU: 0875
Price: 61 USD

Catalog #: 0875
1 Citation Datasheet / COA / SDS

Discontinued Product

0875 has been discontinued.

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m-CPP hydrochloride | CAS No. 13078-15-4 | 5-HT2B Receptor Agonists

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Description: 5-HT2B and 5-HT2C agonist

Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride

Purity: ≥99%

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-HT_2C/2B receptor agonist/partial agonist; displays some activity at 5-HT_2A and 5-HT₁ receptors. pEC₅₀ values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT_2C, _2B and _2A, bovine 5-HT_1A and rat 5-HT_1B receptors respectively. Suppresses locomotor activity in rats in vivo.

Technical Data

M.Wt:

233.14

Formula:

C₁₀H₁₃ClN₂.HCl

Solubility:

Soluble to 100 mM in water

Purity:

≥99%

Storage:

Store at RT

CAS No:

13078-15-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Functional characterization of agonists at recombinant human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors in CHO-K1 cells.
Porter et al.
Br.J.Pharmacol., 1999;128:13
m-CPP: a tool for studying behavioural responses associated with 5-HT_1C receptors.
Curzon et al.
TiPS, 1990;11:181
Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.
Lucki et al.
J.Pharmacol.Exp.Ther., 1989;249:155
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Pharmacol.Rev., 1994;46:157

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Citation for m-CPP hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:

1 Citation: Showing 1 - 1

Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.
Authors: Moya Et al.
BMC Pharmacol 2011;11:3

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