m-CPP hydrochloride

Key Product Details

Product Description

5-HT_2C/2B receptor agonist/partial agonist; displays some activity at 5-HT_2A and 5-HT₁ receptors. pEC₅₀ values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT_2C, _2B and _2A, bovine 5-HT_1A and rat 5-HT_1B receptors respectively. Suppresses locomotor activity in rats in vivo.

Product Specifications for m-CPP hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for m-CPP hydrochloride

The following data is based on the product molecular weight 233.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

8 7 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.29 mL	21.45 mL	42.89 mL
5 mM	0.86 mL	4.29 mL	8.58 mL
10 mM	0.43 mL	2.14 mL	4.29 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Porter Functional characterization of agonists at recombinant human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors in CHO-K1 cells. Br.J.Pharmacol. 1999 PMID: 10498829
• Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165
• Lucki Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 1989 PMID: 2709329
• Curzon m-CPP: a tool for studying behavioural responses associated with 5-HT_1C receptors. TiPS 1990 PMID: 2188399

Product Documents for m-CPP hydrochloride