Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Biological Activity5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
Porter et al.
m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors.
Curzon et al.
Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.
Lucki et al.
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Citation for m-CPP hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:
1 Citation: Showing 1 - 1
Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.
Authors: Moya Et al.
BMC Pharmacol 2011;11:3
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