Catalog Number: 0875
Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Biological Activity
5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.
Technical Data
  • M.Wt:
    233.14
  • Formula:
    C10H13ClN2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    13078-15-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
    Porter et al.
    Br.J.Pharmacol., 1999;128:13
  2. m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors.
    Curzon et al.
    TiPS, 1990;11:181
  3. Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.
    Lucki et al.
    J.Pharmacol.Exp.Ther., 1989;249:155
  4. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
Citations:

The citations listed below are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:

1 Citations: Showing 1 - 1

  1. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.
    Authors: Moya Et al.
    BMC Pharmacol 2011;11:3

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