M4K2163 dihydrochloride

Key Product Details

Product Description

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC₅₀ values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

Product Specifications for M4K2163 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for M4K2163 dihydrochloride

The following data is based on the product molecular weight 480.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Rooney and Jones Recent advances in ALK2 inhibitors. ACS Omega 2021 PMID: 34423181
• Smil Leveraging an open science drug discovery model to develop CNS-penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma. J.Med.Chem. 2020 PMID: 32787083

Product Documents for M4K2163 dihydrochloride