Biological ActivityM617 is a selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
(Modifications: Arg-22 = C-terminal amide)
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Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling.
Mazarati et al.
Activation of peripheral galanin receptors: differential effects on nociception.
Jimenez-Andrade et al.
A galanin receptor subtype 1 specific agonist.
Lundstrom et al.
Citation for M617
The citations listed below are publications that use Tocris products. Selected citations for M617 include:
1 Citation: Showing 1 - 1
Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
Sci Rep 2017;7(1):15317
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