Mandi

Key Product Details

Product Description

Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC₅₀ = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1^Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.

Product Specifications for Mandi

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Mandi

The following data is based on the product molecular weight 411.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.14 mL	24.28 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Park An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity. Nat.Chem.Biol. 2023 PMID: 37872402
• Ziegler Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat.Chem.Biol. 2022 PMID: 34934192

Product Documents for Mandi