Catalog Number: 0711
Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Biological Activity
Selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
Technical Data
  • M.Wt:
    197.13
  • Formula:
    C5H12NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >96%
  • Storage:
    Store at RT
  • CAS No:
    157381-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
    Sekiyama et al.
    Br. J. Pharmacol., 1996;117:1493
  2. Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord.
    Jane et al.
    Br.J.Pharmacol., 1994;112:809
  3. Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices.
    Kemp et al.
    Eur.J.Pharmacol., 1996;309:79
  4. Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo.
    Salt and Eaton
    Neuroscience, 1995;65:5
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MAP4 include:

1 Citations: Showing 1 - 1

  1. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    J Neurosci 2004;101:2151

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