MAP4
Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Purity: ≥96%
Biological Activity
MAP4 is a selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord.
Jane et al.
Br.J.Pharmacol., 1994;112:809 -
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices.
Kemp et al.
Eur.J.Pharmacol., 1996;309:79 -
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
Sekiyama et al.
Br.J.Pharmacol., 1996;117:1493 -
Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo.
Salt and Eaton
Neuroscience, 1995;65:5
Product Datasheets
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Citation for MAP4
The citations listed below are publications that use Tocris products. Selected citations for MAP4 include:
1 Citation: Showing 1 - 1
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Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
Authors: Piet Et al.
J Neurosci 2004;101:2151
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