Catalog Number: 3563
Alternate Names: MgTX
Biological Activity
Potent KV1.3 channel blocker (IC50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 7 - 29, 13 - 34, 17 - 36)

  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purification, characterization, and biosynthesis of Margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.
    Garcia-Calvo et al.
    J.Biol.Chem., 1993;268:18866
  2. Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells.
    Erdogan et al.
    J.Vasc.Res., 2005;42:368
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