Catalog Number: 2631
Alternate Names: BB 2516, Marimistat
Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Biological Activity
Broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
Technical Data
  • M.Wt:
    331.41
  • Formula:
    C15H29N3O5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    154039-60-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.
    Rasmussen and McCann
    Pharmacol.Ther., 1997;75:69
  2. Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition.
    Wada et al.
    Clin.Exp.Metastasis, 2003;20:431
  3. Matrix metalloproteinases participate in osteosarcoma invasion.
    Bjornland et al.
    J.Surg.Res., 2005;127:151
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Marimastat include:

10 Citations: Showing 1 - 10
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  1. Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.
    Authors: Zariffard Et al.
    Hum Reprod 2015;10:e0116911
  2. Nestin depletion induces melanoma matrix metalloproteinases and invasion.
    Authors: Lee Et al.
    Lab Invest 2014;94:1382
  3. Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma.
    Authors: Guo Et al.
    J Exp Clin Cancer Res 2013;32:26
  4. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu.
    Authors: Li Et al.
    J Biol Chem 2013;28:2822
  5. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman Et al.
    PLoS One 2013;20:369
  6. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
    Authors: Mezil Et al.
    PLoS One 2012;7:e43409
  7. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
    Authors: Yurtsever Et al.
    Development 2012;287:42138
  8. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
    Authors: Prendergast Et al.
    Arthritis Res Ther 2012;139:1141
  9. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.
    Authors: Kachgal and Putnam
    Angiogenesis 2011;14:47
  10. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.
    Authors: Ghajar Et al.
    Exp Cell Res 2010;316:813

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