( 17 citations )    
Product Datasheet
Catalog Number:2631
Alternate Names:BB 2516, Marimistat
Chemical Name:(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Product Details
Citations (17)
Biological Activity
Broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for Marimastat include:

17 Citations: Showing 1 - 10
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  1. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures.
    Authors: Bezenah
    Sci Rep  2018;8(1):2671
  2. Matrix degradability controls multicellularity of 3D cell migration.
    Authors: Trappmann
    Nat Commun  2017;8(1):371
  3. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
    Authors: Nicolaou Et al.
    Arterioscler Thromb Vasc Biol  2017;37:247
  4. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
    Authors: Lahey Et al.
    PLoS One  2017;12:e0180259
  5. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
    Authors: Knapinska Et al.
    J Med Chem  2015;58:5808
  6. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways.
    Authors: Ji Et al.
    Br J Cancer  2015;113:921
  7. Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.
    Authors: Zariffard Et al.
    Hum Reprod  2015;10:e0116911
  8. Nestin depletion induces melanoma matrix metalloproteinases and invasion.
    Authors: Lee Et al.
    Lab Invest  2014;94:1382
  9. Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma.
    Authors: Guo Et al.
    J Exp Clin Cancer Res  2013;32:26
  10. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu.
    Authors: Li Et al.
    J Biol Chem  2013;28:2822
  11. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman Et al.
    PLoS One  2013;20:369
  12. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
    Authors: Mezil Et al.
    PLoS One  2012;7:e43409
  13. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
    Authors: Yurtsever Et al.
    Development  2012;287:42138
  14. Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP.
    Authors: Kachgal Et al.
    J Cell Physiol  2012;227:3546
  15. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
    Authors: Prendergast Et al.
    Arthritis Res Ther  2012;139:1141
  16. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.
    Authors: Kachgal and Putnam
    Angiogenesis  2011;14:47
  17. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.
    Authors: Ghajar Et al.
    Exp Cell Res  2010;316:813
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