Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Biological ActivityMarimastat is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.
Rasmussen and McCann
Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition.
Wada et al.
Matrix metalloproteinases participate in osteosarcoma invasion.
Bjornland et al.
Citations for Marimastat
The citations listed below are publications that use Tocris products. Selected citations for Marimastat include:
22 Citations: Showing 1 - 10
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
Authors: Wisdom Et al.
Nat Commun 2018;9:4144
Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures.
Sci Rep 2018;8(1):2671
Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer.
Authors: Megía-Fernández Et al.
Org Biomol Chem 2018;16:8056
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.
Authors: Rosner Et al.
Nat Commun 2017;8:595
Matrix degradability controls multicellularity of 3D cell migration.
Nat Commun 2017;8(1):371
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Authors: Nicolaou Et al.
Arterioscler Thromb Vasc Biol 2017;37:247
Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
Authors: Lahey Et al.
PLoS One 2017;12:e0180259
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Authors: Madoux Et al.
Sci Rep 2016;6:11
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
Authors: Knapinska Et al.
J Med Chem 2015;58:5808
WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways.
Authors: Ji Et al.
Br J Cancer 2015;113:921
Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.
Authors: Zariffard Et al.
Hum Reprod 2015;10:e0116911
Nestin depletion induces melanoma matrix metalloproteinases and invasion.
Authors: Lee Et al.
Lab Invest 2014;94:1382
Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma.
Authors: Guo Et al.
J Exp Clin Cancer Res 2013;32:26
NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu.
Authors: Li Et al.
J Biol Chem 2013;28:2822
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Authors: Brafman Et al.
PLoS One 2013;20:369
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
Authors: Mezil Et al.
PLoS One 2012;7:e43409
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
Authors: Yurtsever Et al.
Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP.
Authors: Kachgal Et al.
J Cell Physiol 2012;227:3546
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
Authors: Prendergast Et al.
Arthritis Res Ther 2012;139:1141
Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.
Authors: Kachgal and Putnam
Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.
Authors: Ghajar Et al.
Exp Cell Res 2010;316:813
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