Potassium channel modulator. Acts as a positive modulator at neuronal Kv
7 channels and calcium-activated K+
) in HEK293 cells. Displays negative modulatory activity at Kv
7.1 channels (Ki
= 3.7 μ
M) and GABAA
receptors. Displays anxiolytic activity in vivo
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Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.
Korsgaard et al.
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.
Jepps et al.
Catalytic enantioselective fluorination of oxindoles.
Hamashima et al.