Catalog Number: 4949
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
Biological Activity
Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.
    Korsgaard et al.
    J.Pharmacol.Exp.Ther., 2005;314:282
  2. One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.
    Jepps et al.
    Br.J.Pharmacol., 2012;168:19
  3. Catalytic enantioselective fluorination of oxindoles.
    Hamashima et al.
    J.Am.Chem.Soc., 2005;127:10164
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