MCL 0020

Catalog # Availability Size / Price Qty
3438/1
MCL 0020
1 Image
Description: Selective MC4 receptor antagonist
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Biological Activity

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.

Technical Data

M.Wt:
609.73
Formula:
C34H39N7O4
Sequence:
XRX

(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 25% ethanol / water
Storage:
Store at -20°C
CAS No:
475498-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
    Chaki et al.
    Eur.J.Pharmacol., 2003;474:95

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