Biological ActivityMCL 0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
Chaki et al.
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