Catalog Number: 3438
Biological Activity
Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
Technical Data
  • M.Wt:
    609.73
  • Formula:
    C34H39N7O4
  • Sequence:
    XRX

    (Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in 25% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
    475498-26-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
    Chaki et al.
    Eur.J.Pharmacol., 2003;474:95

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