Potent and selective melanocortin MC4
receptor antagonist (IC50
values are 11.63, 1115 and > 10 000 nM at MC4
receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo
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Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
Chaki et al.