Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Biological ActivityMcN-A 343 is a selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.
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Muscarinic receptor subtypes and smooth muscle function.
Eglen et al.
Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors.
Davies et al.
Functional determination of McN-A-343 affinity for M1 muscarinic receptors.
Micheletti and Schiavone
Citations for McN-A 343
The citations listed below are publications that use Tocris products. Selected citations for McN-A 343 include:
2 Citations: Showing 1 - 2
Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.
Authors: Deng Et al.
J Pharmacol Toxicol Methods 2013;68:323
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
Authors: Park Et al.
Korean J Anesthesiol 2013;38:1426
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