McN-A 343

Key Product Details

Product Description

McN-A 343 is a selective muscarinic M₁ receptor agonist. Selectivity for M₁ over other muscarinic receptor types appears to arise from a high efficacy at M₁ receptors.

Product Specifications for McN-A 343

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for McN-A 343

The following data is based on the product molecular weight 317.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Eglen Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 1996 PMID: 8981565
• Micheletti and Schiavone Functional determination of McN-A-343 affinity for M₁ muscarinic receptors. J.Pharmacol.Exp.Ther. 1990 PMID: 1691785
• Davies Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M₁ receptors. J.Pharm.Pharmacol. 2001 PMID: 11341365

Product Documents for McN-A 343