Catalog Number: 1384
Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Biological Activity
Selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.
Technical Data
  • M.Wt:
    317.21
  • Formula:
    C14H18Cl2N2O2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    55-45-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Muscarinic receptor subtypes and smooth muscle function.
    Eglen et al.
    Pharmacol.Rev., 1996;48:531
  2. Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors.
    Davies et al.
    J.Pharm.Pharmacol., 2001;53:487
  3. Functional determination of McN-A-343 affinity for M1 muscarinic receptors.
    Micheletti and Schiavone
    J.Pharmacol.Exp.Ther., 1990;253:310
Citations:

The citations listed below are publications that use Tocris products. Selected citations for McN-A 343 include:

1 Citations: Showing 1 - 1

  1. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
    Authors: Park Et al.
    Korean J Anesthesiol 2013;38:1426

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