Chemical Name: 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
Biological ActivityMCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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A high-throughput screening identifies MICU1 targeting compounds.
Di Marco et al.
Cell Rep., 2020;30:2321
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