Selective inhibitor of Dnm1 GTPase (IC50
= 1 - 10 μ
M); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.
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A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
Tanaka and Youle
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
Lackner et al.
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Cassidy-Stone et al.