Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Biological ActivityMdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
Tanaka and Youle
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
Lackner et al.
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Cassidy-Stone et al.
Citations for Mdivi 1
The citations listed below are publications that use Tocris products. Selected citations for Mdivi 1 include:
4 Citations: Showing 1 - 4
Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.
Authors: Tsuyoshi Et al.
Mdivi-1 attenuates sodium azide-induced apoptosis in H9c2 cardiac muscle cells.
Authors: Xu Et al.
Mol Med Rep 2017;16:5972
Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts.
Am J Physiol Cell Physiol 2014;306:C1176
Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor.
Authors: Gharanei Et al.
PLoS One 2013;8:e77713
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