Catalog Number: 3982
Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Biological Activity
Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.
Technical Data
  • M.Wt:
    353.22
  • Formula:
    C15H10Cl2N2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    338967-87-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
    Tanaka and Youle
    Mol.Cell, 2008;29:409
  2. Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
    Lackner et al.
    Chem.Biol., 2010;17:57
  3. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
    Cassidy-Stone et al.
    Develop.Cell, 2008;14:193
  4. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;

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