Mdivi 1

Catalog # Availability Size / Price Qty
3982/10
3982/50
Dynamin Inhibitors Small Molecule
1 Image
Description: Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.

Technical Data

M.Wt:
353.22
Formula:
C15H10Cl2N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
338967-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
  2. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
    Tanaka and Youle
    Mol.Cell, 2008;29:409
  3. Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
    Lackner et al.
    Chem.Biol., 2010;17:57
  4. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
    Cassidy-Stone et al.
    Develop.Cell, 2008;14:193

Product Datasheets

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Citations for Mdivi 1

The citations listed below are publications that use Tocris products. Selected citations for Mdivi 1 include:

4 Citations: Showing 1 - 4

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