MDL 12330A hydrochloride (CAS 40297-09-4): R&D Systems
Catalog Number: 1436
Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride
Biological Activity
Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.
Technical Data
  • M.Wt:
    377.01
  • Formula:
    C23H36N2.HCl
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    40297-09-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations.
    Hunt and Evans
    Biochim.Biophys.Acta, 1980;613:499
  2. RMI 12330 A, an inhibitor of adenylate cyclase in rat liver.
    Guellaen et al.
    Biochim.Biophys.Acta, 1977;484:465
  3. Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function.
    van Rossum et al.
    J.Biol.Chem., 2000;275:28562

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