Potent, selective inhibitor of calpain and cathepsin B (Ki
values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo
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Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170.
Chen et al.
Brain Res., 1997;769:188
Cell-penetrating inhibitor of calpain.
Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.
Li et al.
Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
Ai et al.
The citations listed below are publications that use Tocris products. Selected citations for MDL 28170 include:
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