Catalog Number: 1146
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Biological Activity
Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170.
    Chen et al.
    Brain Res., 1997;769:188
  2. Cell-penetrating inhibitor of calpain.
    TiBS, 1991;16:150
  3. Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.
    Li et al.
    Neurosci.Lett., 1998;247:17
  4. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
    Ai et al.
    J.Neurotrauma, 2007;24:960

The citations listed below are publications that use Tocris products. Selected citations for MDL 28170 include:

Showing Results 1 - 2 of 2

  1. ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
    Authors: Bill Et al.
    J Neurosci
  2. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol
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