Me VH 032, amine

Tocris Bioscience | Catalog # 7634

Amine functionalized VHL ligand for PROTAC® research
Tocris Bioscience

Key Product Details

Description

Amine functionalized VHL ligand for PROTAC® research
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Product Description

Me VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Me VH 032, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand. Introduction of the methyl group at the benzylic position of VH 032 is associated with improved binding affinity.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Me VH 032, amine

Molecular Weight

517.51

Formula

C23H32N4O3S.2HCl

Storage

Desiccate at RT

Purity

≥95% (HPLC)

Chemical Name

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride

CAS Number

2504950-56-3

PubChem ID

137319712

InChI Key

YTJDUDNKHHNDRD-ARZBPYMHSA-N

SMILES

CC1=C(C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Me VH 032, amine

Certificate of Analysis

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Product Specific Notices for Me VH 032, amine

For research use only

Citations for Me VH 032, amine

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