Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1
receptor antagonist. Confers neuroprotection in models of polyQ toxicity.
Soluble to 50 mM in DMSO
Desiccate at RT
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The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
Parada et al.
Meclizine is neuroprotective in models of Huntington's disease.
Gohil et al.
Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
Lau et al.