Catalog Number: 4245
Alternate Names: Meclozine
Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Biological Activity
Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
    Parada et al.
    Neuroscience, 2001;102:937
  2. Meclizine is neuroprotective in models of Huntington's disease.
    Gohil et al.
    Hum.Mol.Genet., 2010;20:294
  3. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
    Lau et al.
    J.Pharmacol.Exp.Ther., 2011;336:816
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