Meclizine dihydrochloride

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Meclizine dihydrochloride | CAS No. 1104-22-9 | Pregnane X Receptor Agonists
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Description: Human pregnane X receptor agonist; H1 antagonist
Alternative Names: Meclozine

Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Technical Data

Soluble to 50 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Meclizine dihydrochloride

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