Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Biological ActivityMeclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
Parada et al.
Meclizine is neuroprotective in models of Huntington's disease.
Gohil et al.
Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
Lau et al.
Citations for Meclizine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Meclizine dihydrochloride include:
2 Citations: Showing 1 - 2
Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease.
Authors: Oosterveen Et al.
Stem Cell Reports 2021;16:2718
Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models.
Authors: Hong Et al.
Sci Rep 2016;6:25344
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