Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid
Biological ActivityFree fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
Hara et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2009;380:247
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats.
Atkinson et al.
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