Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid
Biological ActivityMEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
Hara et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2009;380:247
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in Ins-resistant JCR:LA-cp rats.
Atkinson et al.
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