Mefloquine hydrochloride

Catalog # Availability Size / Price Qty
6819/50
Gap Channel Blockers Small Molecule
1 Image
Description: Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal

Chemical Name:S)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Cx36 and Cx50 gap channel blocker (IC50 values are 0.3 and 1.1 μM, resepctively). Blocks gap junctional-coupling between interneurons in neocortical slices. Also antimalarial. Bind 80S ribosome of Plasmodium falciparum to inhibit protein synthesis. Improves survival in P berghei-infected mice. Additionally exhibits antischistosomal activity in vitro and in vivo.

Technical Data

M.Wt:
414.77
Formula:
C17H16F6N2O.HCl
Solubility:
Soluble to 100 mM in ethanol and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
51773-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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