Chemical Name: (αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
Biological ActivityCx36 and Cx50 gap channel blocker (IC50 values are 0.3 and 1.1 μM, resepctively). Blocks gap junctional-coupling between interneurons in neocortical slices. Also antimalarial. Bind 80S ribosome of Plasmodium falciparum to inhibit protein synthesis. Improves survival in P berghei-infected mice. Additionally exhibits antischistosomal activity in vitro and in vivo. Exhibits antiviral activities against SARS-CoV-2 (IC50 < 10 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture Pathogen Box.
Pasche et al.
ACS Infect.Dis., 2019;5:102
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Wong et al.
Antimalarials. 7. Bis(trifluoromethyl)-α-(2-piperidyl)-4-quinolinemethanols.
Ohnmacht et al.
Potent block of Cx36 and Cx50 gap junction channels by meflo.
Cruikshank et al.
Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs.
Jeon et al.
Antimicrob.Agents Chemother., 2020;
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