Catalog Number: 2566
Alternate Names: MT-II
Biological Activity
High affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = Nle & N-terminal Ac, Asp-2 = beta-Asp, Phe-4 = D-Phe, Lys-7 = epsilon-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula.
    Martin et al.
    Eur.J.Pharmacol., 2002;454:71
  2. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.
    Ter Laak et al.
    Eur.J.Pharmacol., 2003;462:179
  3. Melanocortin receptors: perspectives for novel drugs.
    Eur.J.Pharmacol., 1999;375:395
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