Biological ActivityHigh affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
(Modifications: X = Nle & N-terminal Ac, Asp-2 = beta-Asp, Phe-4 = D-Phe, Lys-7 = epsilon-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula.
Martin et al.
The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.
Ter Laak et al.
Melanocortin receptors: perspectives for novel drugs.
Citation for Melanotan II
The citations listed below are publications that use Tocris products. Selected citations for Melanotan II include:
1 Citation: Showing 1 - 1
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
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