Melatonin

Tocris Bioscience | Catalog # 3550

Endogenous hormone; agonist at MT1 and MT2
Tocris Bioscience

Key Product Details

Description

Endogenous hormone; agonist at MT1 and MT2
View all Melatonin (MT) Receptor Agonists »

Product Description

Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Product Specifications for Melatonin

Molecular Weight

232.28

Formula

C13H16N2O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Acetyl-5-methoxytryptamine

CAS Number

73-31-4

PubChem ID

896

InChI Key

DRLFMBDRBRZALE-UHFFFAOYSA-N

SMILES

O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.61 50

Preparing Stock Solutions for Melatonin

The following data is based on the product molecular weight 232.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.61 mL 43.05 mL 86.10 mL
2.5 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
25 mM 0.17 mL 0.86 mL 1.72 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 51 publications citing the usage of this product.

Product Documents for Melatonin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Melatonin

For research use only

Customer Reviews for Melatonin (1)

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  • Excellent choice for interaction studies with melatonin receptors
    Name: Benjamin Stauch
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/11/2022
    This product is an excellent choice for in vitro interaction studies with melatonin receptors. Given that its the endogenous ligand of these receptors, it offers an important point of comparison when testing ligands with unknown activity profiles. In our lab, we typically use this product in micromolar concentrations in all buffers when handling melatonin receptors, unless a more highly stabilizing or potent ligand (such as 2-phenylmelatonin or ramelteon) is needed. These ligands can be more expensive, making melatonin preferable in some cases. We found this product consistently of the highest quality. Highly recommended

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