Chemical Name: N-Acetyl-5-methoxytryptamine
Biological ActivityEndogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Thirty four years since the discovery of gastrointestinal melatonin.
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair.
Fischer et al.
Melatonin and melatonergic drugs on sleep: possible mechanisms of action.
Cardinali et al.
Citations for Melatonin
The citations listed below are publications that use Tocris products. Selected citations for Melatonin include:
7 Citations: Showing 1 - 7
Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression.
Authors: Fernandes Et al.
Front Cell Infect Microbiol 2019;9:60
A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice.
Authors: Costa Et al.
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Authors: Chen Et al.
Toxicol Sci 2014;20:1298
Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons.
Authors: Huang Et al.
Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels.
Authors: Giordano Et al.
Toxicol Appl Pharmacol 2008;232:161
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