Melperone hydrochloride

Key Product Details

Product Description

Melperone hydrochloride is an atypical neuroleptic; 5-HT_2A/D₂ receptor antagonist (K_i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α₁ and α₂ receptors (K_i values are 180 and 150 nM respectively).

Product Specifications for Melperone hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Melperone hydrochloride

The following data is based on the product molecular weight 299.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.35 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Ichikawa Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase DA and acetylcholine release in rat medial prefrontal cortex: role of 5-HT_1A receptor agonism. Brain Res. 2002 PMID: 12445705
• Uhr P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol.
• Seeman Atypical neuroleptics have low affinity for DA D₂ receptors or are selective for D₄ receptors. Neuropsychopharmacology. 1997 PMID: 9015795

Product Documents for Melperone hydrochloride