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Melperone hydrochloride

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Melperone hydrochloride | CAS No. 1622-79-3 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A antagonist; also D2 antagonist; neuroleptic

Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride

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Citations (1)
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Biological Activity

Atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).

Technical Data

Formula:
C16H22FNO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
1622-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Atypical neuroleptics have low affinity for DA D2 receptors or are selective for D4 receptors.
    Seeman et al.
    Neuropsychopharmacology., 1997;16:93
  2. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase DA and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
    Ichikawa et al.
    Brain Res., 2002;956:349
  3. P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.
    Uhr et al.
    J.Psychopharmacol., 2005;18:509

Product Datasheets

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Citation for Melperone hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Melperone hydrochloride include:

1 Citation: Showing 1 - 1

  1. Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of MetF. with Experimental Substrates.
    Authors: Hacker Et al.
    Brain Res  2015;10:e0136451

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VersaClone cDNA Plasmids

Human 5-HT2A (NP_000612) VersaClone cDNA

RDC0288

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