Atypical neuroleptic; 5-HT2A
receptor antagonist (Ki
values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1
values are 180 and 150 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
Seeman et al.
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
Ichikawa et al.
Brain Res., 2002;956:349
P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.
Uhr et al.
The citations listed below are publications that use Tocris products. Selected citations for Melperone hydrochloride include:
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