Catalog Number: 2495
Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
Biological Activity
Atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
    Seeman et al.
    Neuropsychopharmacology., 1997;16:93
  2. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
    Ichikawa et al.
    Brain Res., 2002;956:349
  3. P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.
    Uhr et al.
    J.Psychopharmacol., 2005;18:509

The citations listed below are publications that use Tocris products. Selected citations for Melperone hydrochloride include:

Showing Results 1 - 1 of 1

  1. Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates.
    Authors: Hacker Et al.
    Brain Res
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