Melphalan
Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Purity: ≥95%
Biological Activity
Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence.
Bauer and Povirk
Nucleic Acids Res., 1997;25:1211 -
An alkylating agent for multiple myeloma: melp.
Blumberg et al.
JAMA., 1965;191:547 -
In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer.
Mougenot et al.
Anticancer Res., 2006;26:2197
Product Datasheets
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Citations for Melphalan
The citations listed below are publications that use Tocris products. Selected citations for Melphalan include:
2 Citations: Showing 1 - 2
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Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Authors: Carlos Et al.
EMBO Mol Med 2019;11:e9982
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Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Authors: Carlos Et al.
EMBO Mol Med 2019;
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