Catalog Number: 4619
Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Biological Activity
DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).
Technical Data
  • M.Wt:
    305.2
  • Formula:
    C13H18Cl2N2O2
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in 1eq. HCl
  • Purity:
    >95%
  • Storage:
    Store at RT
  • CAS No:
    148-82-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. An alkylating agent for multiple myeloma: melphalan.
    Blumberg et al.
    JAMA., 1965;191:547
  3. Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence.
    Bauer and Povirk
    Nucleic Acids Res., 1997;25:1211
  4. In vitro cytotoxic effect of melphalan and pilot phase II study in hormone-refractory prostate cancer.
    Mougenot et al.
    Anticancer Res., 2006;26:2197

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