Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Biological ActivityMelphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence.
Bauer and Povirk
Nucleic Acids Res., 1997;25:1211
An alkylating agent for multiple myeloma: melp.
Blumberg et al.
In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer.
Mougenot et al.
Anticancer Res., 2006;26:2197
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