Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Biological ActivityDNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence.
Bauer and Povirk
Nucleic Acids Res., 1997;25:1211
An alkylating agent for multiple myeloma: melp.
Blumberg et al.
In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer.
Mougenot et al.
Anticancer Res., 2006;26:2197
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Melphalan
There are currently no reviews for this product. Be the first to review Melphalan and earn rewards!
Have you used Melphalan?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image