Mepyramine maleate

  ( 4 citations )    
Product Datasheet
Catalog Number:0660
Alternate Names:Pyrilamine maleate
Chemical Name:2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.
Technical Data
  • M.Wt:
    401.46
  • Formula:
    C17H23N3O.C4H4O4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    59-33-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mepyramine maleate include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
    Authors: Kurtz Et al.
    Microcirculation  2014;21:593
  2. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
    Authors: Connelly Et al.
    Br J Pharmacol  2009;157:55
  3. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
    Authors: Flamand Et al.
    Br J Pharmacol  2004;141:552
  4. Mast cells are required for experimental oral allergen-induced diarrhea.
    Authors: Brandt Et al.
    J Clin Invest  2003;112:1666

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Mepyramine maleate?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee