Chemical Name: 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
Biological ActivityMepyramine maleate is a selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mepyramine, a histamine H1 receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein.
Carlos et al.
Distribution, properties and functional characteristics of three classes of histamine receptor.
Does the [3H] mepyramine binding site represent the histamine H1 receptor? Re-examination of the histamine H2 receptor with qine
Liu et al.
Citations for Mepyramine maleate
The citations listed below are publications that use Tocris products. Selected citations for Mepyramine maleate include:
5 Citations: Showing 1 - 5
A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells.
Authors: Littmann Et al.
Sci Rep 2018;8:17179
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Authors: Kurtz Et al.
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Authors: Connelly Et al.
Br J Pharmacol 2009;157:55
Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552
Mast cells are required for experimental oral allergen-induced diarrhea.
Authors: Brandt Et al.
J Clin Invest 2003;112:1666
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Mepyramine maleate
There are currently no reviews for this product. Be the first to review Mepyramine maleate and earn rewards!
Have you used Mepyramine maleate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image