Methotrexate

Catalog # Availability Size / Price Qty
1230/100
Methotrexate | CAS No. 59-05-2 | Cell Cycle Inhibitors
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Description: Cytotoxic agent

Chemical Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Methotrexate is a cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation.

Technical Data

M.Wt:
454.44
Formula:
C20H22N8O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
59-05-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Methotrexate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Methotrexate

The citations listed below are publications that use Tocris products. Selected citations for Methotrexate include:

2 Citations: Showing 1 - 2

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