Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Biological ActivityFluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
Bolmont et al.
PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
Yamanaka et al.
Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Klunk et al.
Citations for Methoxy-X04
The citations listed below are publications that use Tocris products. Selected citations for Methoxy-X04 include:
7 Citations: Showing 1 - 7
Cellular and Molecular Probing of Intact Human Organs
Authors: Zhao Et al.
Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.
Authors: Medrano-Jimé nez Et al.
J Neuroinflammation 2019;16:143
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Authors: Plog Et al.
JCI Insight 2018;3
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.
Authors: Blume Et al.
J Neuroinflammation 2018;15:307
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Authors: Ulland Et al.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Authors: Möhle Et al.
Acta Neuropathol Commun 2016;4:25
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Authors: Fu Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Methoxy-X04
Average Rating: 4.5 (Based on 2 Reviews)
Have you used Methoxy-X04?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
The hippocampal slices from mice brain was dyed with methoxy X04 in PBS-EtOH solution. The slices were kept in dark and were then mounted with dako vector mounting media
Injected IV, Methoxy-X04 labels amyloid plaques in AD models. Great tool to image various cellular processes around AD plaques.