Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Biological ActivityMethoxy-X04 is a fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Methoxy-X04 displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Methoxy-X04 is a derivative of Congo Red (Cat. No. 5167). Methoxy-X04 can be used for in vivo Aβ plaque labeling. Methoxy-X04 co-localizes with CD68+ phagosomes in plaque-associated Iba1+ microglia; and it labels molecularly distinct plaque-associated microglia populations. Brain penetrant.
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Complete Your Research
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
Bolmont et al.
PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
Yamanaka et al.
Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Klunk et al.
Citations for Methoxy-X04
The citations listed below are publications that use Tocris products. Selected citations for Methoxy-X04 include:
8 Citations: Showing 1 - 8
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
Authors: Socodato Et al.
Cell Rep 2020;31
Cellular and Molecular Probing of Intact Human Organs
Authors: Zhao Et al.
Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism.
Authors: Medrano-Jimé nez Et al.
J Neuroinflammation 2019;16:143
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Authors: Plog Et al.
JCI Insight 2018;3
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.
Authors: Blume Et al.
J Neuroinflammation 2018;15:307
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Authors: Ulland Et al.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Authors: Möhle Et al.
Acta Neuropathol Commun 2016;4:25
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Authors: Fu Et al.
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