Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Biological ActivityFluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
Bolmont et al.
PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
Yamanaka et al.
Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Klunk et al.
Citations for Methoxy-X04
The citations listed below are publications that use Tocris products. Selected citations for Methoxy-X04 include:
5 Citations: Showing 1 - 5
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Authors: Plog Et al.
JCI Insight 2018;3
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.
Authors: Blume Et al.
J Neuroinflammation 2018;15:307
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Authors: Ulland Et al.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Authors: Möhle Et al.
Acta Neuropathol Commun 2016;4:25
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Authors: Fu Et al.
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Reviews for Methoxy-X04
Average Rating: 5 (Based on 1 Review)
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Injected IV, Methoxy-X04 labels amyloid plaques in AD models. Great tool to image various cellular processes around AD plaques.