Catalog Number: 4920
Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Biological Activity
Fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
Technical Data
  • M.Wt:
    344.4
  • Formula:
    C23H20O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    863918-78-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
    Bolmont et al.
    J.Neurosci., 2008;28:4283
  2. PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
    Yamanaka et al.
    J.Neurosci., 2012;32:17321
  3. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
    Klunk et al.
    J.Neuropathol.Exp.Neurol., 2002;61:797
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Methoxy-X04 include:

1 Citations: Showing 1 - 1

  1. IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
    Authors: Fu Et al.
    Elife 2016;113:E2705

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