Catalog Number: 3213
Chemical Name: 3,7-bis(Dimethylamino)phenazathionium chloride
Biological Activity
Biological stain and redox indicator. Inhibits tau filament formation (IC50 = 1.9 μM). Also inhibits soluble guanylyl cyclase.
Technical Data
  • M.Wt:
    319.85
  • Formula:
    C16H18ClN3S
  • Solubility:
    Soluble to 10 mM in water and to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    61-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of two soluble guanylyl cyclase inhibitors, methylene boue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
    Hwang et al.
    Br.J.Pharmacol., 1998;125:1158
  2. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.
    Taniguchi et al.
    J.Biol.Chem., 2005;280:7614
  3. Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
    Wischik et al.
    Neurobiology, 1996;93:11213

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