Rotenone

Catalog # Availability Size / Price Qty
3616/50
Rotenone | CAS No. 83-79-4 | Oxidative Phosphorylation Inhibitors
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Description: Inhibits complex I of the mitochondrial electron transport chain

Chemical Name: (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Purity: ≥95%

Product Details
Citations (7)
Reviews (1)

Biological Activity

Mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

Technical Data

M.Wt:
394.42
Formula:
C23H22O6
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥95%
Storage:
Store at RT
CAS No:
83-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Good choice!
By Anton Mukhamedshin on 02/22/2019
Species: Human

I use it to inhibit mitochondrial electron transport chain in platelets. It helps to understand the role of mitochondrial in thrombosis


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