Rotenone

  ( 4 citations )    
Product Datasheet
Catalog Number:3616
Chemical Name:(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Product Details
Citations (4)
Reviews
Biological Activity
Mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.
Technical Data
  • M.Wt:
    394.42
  • Formula:
    C23H22O6
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >95
  • Storage:
    Store at RT
  • CAS No:
    83-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rotenone include:

4 Citations: Showing 1 - 4
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  1. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22(phox)-derived reactive oxygen species in acute myeloid leukemia.
    Authors: Moloney Et al.
    Leuk Res  2017;52:34
  2. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
    Authors: Banh Et al.
    Nat Cell Biol  2016;18:803
  3. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
    Authors: Beyer Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H1587
  4. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
    Authors: Juliana Et al.
    Leukemia  2012;287:36617

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