Rotenone
Chemical Name: (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Purity: ≥95%
Biological Activity
Rotenone is a mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Rotenone inhibits autophagic flux prior to inducing cell death.
Mader et al.
ACS Chem.Neurosci., 2012;3:1063 -
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release.
Cherednichenko et al.
Circ.Res., 2004;94:478 -
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
Uversky
Cell Tissue Res., 2004;318:225 -
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
Gomez et al.
Front.Biosci., 2007;12:1079
Product Datasheets
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Citations for Rotenone
The citations listed below are publications that use Tocris products. Selected citations for Rotenone include:
7 Citations: Showing 1 - 7
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High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
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Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Neuron 2017;93:587
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Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22(phox)-derived reactive oxygen species in acute myeloid leukemia.
Authors: Moloney Et al.
Leuk Res 2017;52:34
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A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.
Authors: Martin Et al.
Cell Rep 2017;20:427
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PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
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An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
Authors: Beyer Et al.
Am J Physiol Heart Circ Physiol 2014;307:H1587
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Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
Authors: Juliana Et al.
Leukemia 2012;287:36617
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