Mitochondrial electron transport chain inhibitor (IC50
= 1.7 - 2.2 μ
M at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50
= 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release.
Cherednichenko et al.
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
Cell Tissue Res., 2004;318:225
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
Gomez et al.
Rotenone inhibits autophagic flux prior to inducing cell death.
Mader et al.
ACS Chem.Neurosci., 2012;3:1063
The citations listed below are publications that use Tocris products. Selected citations for Rotenone include:
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