Methylprednisolone

Tocris Bioscience | Catalog # 4819

Glucocorticoid receptor agonist
Tocris Bioscience

Key Product Details

Description

Glucocorticoid receptor agonist
View all Glucocorticoid Receptor Agonists »

Product Description

Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Methylprednisolone

Molecular Weight

374.47

Formula

C22H30O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

CAS Number

83-43-2

PubChem ID

6741

InChI Key

VHRSUDSXCMQTMA-PJHHCJLFSA-N

SMILES

O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.45 100

Preparing Stock Solutions for Methylprednisolone

The following data is based on the product molecular weight 374.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.35 mL 26.70 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Methylprednisolone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Methylprednisolone

For research use only

Citations for Methylprednisolone

Customer Reviews for Methylprednisolone (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Methylprednisolone?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Anti-inflammatory effects in neural tissue
    Name: Luiz Alexandre Magno
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 02/17/2022
    Its is very important to perform a time response curve to get the best results.
    This anti-inflammatory decreases inflammation in neural tissue. Pretreatment with this drug is able to decrease the proliferation of glial cells (see the image, right side). This experimental model is useful to create comparisons with new drugs to be tested.
    Methylprednisolone 4819

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All