Catalog Number: 4819
Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Biological Activity
Glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
Technical Data
  • M.Wt:
    374.47
  • Formula:
    C22H30O5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    83-43-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.
    Lee et al.
    J.Neurosci., 2008;29:3141
  2. STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes.
    Xu et al.
    J.Neurosci., 2009;29:2022

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