Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Biological ActivityMethylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.
Lee et al.
STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes.
Xu et al.
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