Glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL
via direct binding of the GR/STAT5 complex. Neuroprotective.
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Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.
Lee et al.
STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes.
Xu et al.