Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Biological ActivityGlucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-x L via direct binding of the GR/STAT5 complex. Neuroprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.
Lee et al.
STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes.
Xu et al.
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