Catalog Number: 3292
Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propanone
Biological Activity
Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyrapone analogues.
    Hays et al.
    J.Med.Chem., 1984;27:15
  2. Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells.
    Asakura and Shichi
    Exp.Eye Res., 1992;55:377
  3. Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4.
    Park et al.
    J.Am.Chem.Soc., 2005;127:13634

The citations listed below are publications that use Tocris products. Selected citations for Metyrapone include:

Showing Results 1 - 2 of 2

  1. Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction.
    Authors: Rincón-Cortés Et al.
    Brain Res
  2. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain
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