Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β
hydroxylase (CYP11B1) activity (IC50
= 7.83 μ
M). Also inhibits CYP3A4 and cytochrome P450-mediated ω
-1 hydroxylase activity.
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyrapone analogues.
Hays et al.
Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells.
Asakura and Shichi
Exp.Eye Res., 1992;55:377
Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4.
Park et al.
The citations listed below are publications that use Tocris products. Selected citations for Metyrapone include:
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