Metyrapone

  ( 3 citations )    
Product Datasheet
Catalog Number:3292
Chemical Name:2-Methyl-1,2-di-3-pyridinyl-1-propanone
Product Details
Citations (3)
Reviews
Biological Activity
Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.
Technical Data
  • M.Wt:
    226.27
  • Formula:
    C14H14N2O
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    54-36-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Metyrapone include:

3 Citations: Showing 1 - 3
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  1. Lymphoid organs of neonatal and adult mice preferentially produce active glucocorticoids from metabolites, not precursors.
    Authors: Taves Et al.
    Brain Behav.Immun.  2016;57:271
  2. Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction.
    Authors: Rincón-Cortés Et al.
    Brain Res  2015;112:881
  3. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain  2014;7:32

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