Potent cell-permeable inhibitor of proteasome (IC50
= 100 nM) and calpain (IC50
= 1.2 μ
M). Inhibits TNF-α
B activation and Iκ
degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination.
Banerjee and Liefshitz
Anticancer Res., 2001;21:3941
The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB.
Palombella et al.
Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine.
Tsubuki et al.
The citations listed below are publications that use Tocris products. Selected citations for MG 132 include:
Showing Results 1 - 10 of 33