Mibefradil dihydrochloride

Tocris Bioscience | Catalog # 2198

CaV3.x blocker
Tocris Bioscience

Key Product Details

Description

CaV3.x blocker

Alternative Names

Ro 40-5967
View all Cav3.x Channel Blockers »

Product Description

Mibefradil dihydrochloride is a Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Product Specifications for Mibefradil dihydrochloride

Molecular Weight

568.56

Formula

C29H38FN3O3.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

CAS Number

116666-63-8

PubChem ID

60662

InChI Key

MTJLQTFHJIHXIX-GDUXWEAWSA-N

SMILES

Cl.Cl.COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=C(N2)C=CC=C3)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.43 50
DMSO 56.86 100

Preparing Stock Solutions for Mibefradil dihydrochloride

The following data is based on the product molecular weight 568.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.79 mL 17.59 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for Mibefradil dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mibefradil dihydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Mibefradil dihydrochloride

Customer Reviews for Mibefradil dihydrochloride (1)

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  • Mibefradil dihydrochloride used on T type calcium channels
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/13/2019
    Mibefradil dihydrochloride used on T type calcium channels that aid in mediating calcium influx into cells after an action potential or depolarizing signal. The entry of calcium into various cells has many different physiological responses associated with it.
    Mibefradil dihydrochloride 2198

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