Catalog Number: 2198
Alternate Names: Ro 40-5967
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Biological Activity
Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.
Technical Data
  • M.Wt:
    568.56
  • Formula:
    C29H38FN3O3.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    116666-63-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action.
    Osterrieder and Holck
    J.Cardiovasc.Pharmacol., 1989;13:754
  2. Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine.
    Veniant et al.
    J.Cardiovasc.Pharmacol., 1991;18:S55
  3. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels.
    Mehrke et al.
    J.Pharmacol.Exp.Ther., 1994;271:1483
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mibefradil dihydrochloride include:

7 Citations: Showing 1 - 7
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  1. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    Authors: Weber
    PLoS One 2017;12(3):e0172491
  2. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina
    Authors: Prigge Et al.
    The Journal of Neuroscience 2016;6:7184
  3. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
    Authors: Wang Et al.
    Nature 2015;5:16768
  4. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels.
    Authors: Stone Et al.
    Sci Rep 2013;543:177
  5. Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells.
    Authors: Weick and Demb
    Neuron 2011;71:166
  6. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
    Authors: Grubb and Burrone
    Neurosci Lett 2010;465:1070
  7. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958

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