Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Biological ActivityMibefradil dihydrochloride is a Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action.
Osterrieder and Holck
The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels.
Mehrke et al.
Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlod.
Veniant et al.
Citations for Mibefradil dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mibefradil dihydrochloride include:
9 Citations: Showing 1 - 9
Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
PLoS One 2017;12(3):e0172491
Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
Authors: Bragança Et al.
Front Pharmacol 2016;7:45
M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina
Authors: Prigge Et al.
The Journal of Neuroscience 2016;6:7184
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
Authors: Wang Et al.
DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels.
Authors: Stone Et al.
Sci Rep 2013;543:177
Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells.
Authors: Weick and Demb
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
Authors: Grubb and Burrone
Neurosci Lett 2010;465:1070
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
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Mibefradil dihydrochloride used on T type calcium channels that aid in mediating calcium influx into cells after an action potential or depolarizing signal. The entry of calcium into various cells has many different physiological responses associated with it.