Catalog Number: 2198
Alternate Names: Ro 40-5967
Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Biological Activity
Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action.
    Osterrieder and Holck
    J.Cardiovasc.Pharmacol., 1989;13:754
  2. Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine.
    Veniant et al.
    J.Cardiovasc.Pharmacol., 1991;18:S55
  3. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels.
    Mehrke et al.
    J.Pharmacol.Exp.Ther., 1994;271:1483
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